Protein name:
Bile acid receptor ;
Alternative:
Farnesol receptor HRR-1 ;Farnesoid X-activated receptor ;Nuclear receptor subfamily 1 group H member 4 ;
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Heterodimer of NR1H4 and RXR. Interacts with CARM1 and SMARD1. After activation by agonist binding, interacts with a coactivator, NCOA1 or NCOA2.
Function:
Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) and activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 within its gene locus.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MVMQFQELEN | PVQISPCHSH | TSSGFDMEVM | SMKPAKGVLT | EQVAGPLGQN |
100:
LEVEPYSQYN | NVQFPQVQPQ | ISSSSYYSNV | GFYPQQPEEW | YSPGIYELRR |
150:
MPAETLYQGE | TEVVEIPITK | KARLGASAGR | IKGDELCVVC | GDRASGYHYN |
200:
ALTCEGCKGF | FRRSITKNAV | YKCKNGGNCV | MDMYMRRKCQ | ECRLRKCKEM |
250:
GMLAECLLTE | IQCKSKRLRK | NVKQHADQAI | HEDSEGRDLR | QVTSTTKSCR |
300:
EKTELTPDQQ | NLLHYIMDSY | SKQRMPQEIT | NKFLKEEFSA | EENFIILTEM |
350:
ATSHVQVLVE | FTKKLPGFQT | LDHEDQIALL | KGSAVEAMFL | RSAEIFSKKL |
400:
PAGHTDLLEE | RIRKSGISDE | YITPMFSFYK | SVAELKMTQE | EYALLTAIVI |
450:
LSPDRQYIKD | REAVEKLQEP | LLDVLQKLCK | IHQPENPQHF | ACLLGRLTEL |
482:
RTFNHHHADM | LMSWRVNDHK | FTPLLCEIWD | VQ
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Bovine
ELISA Kit for Bovine Bile acid receptor
ELISA Kit for Bovine Bile acid receptor
ELISA Kit for Bovine Bile acid receptor
ELISA Kit for Bovine Bile acid receptor
CLIA Kit for Bovine Bile acid receptor
CLIA Kit for Bovine Bile acid receptor
CLIA Kit for Bovine Bile acid receptor
CLIA Kit for Bovine Bile acid receptor
Polyclonal Antibody for Bovine Bile acid receptor
Polyclonal Antibody for Bovine Bile acid receptor
Polyclonal Antibody for Bovine Bile acid receptor
Polyclonal Antibody for Bovine Bile acid receptor
Monoclonal Antibody for Bovine Bile acid receptor
Monoclonal Antibody for Bovine Bile acid receptor
Monoclonal Antibody for Bovine Bile acid receptor
Monoclonal Antibody for Bovine Bile acid receptor
Protein for Bovine Bile acid receptor
Protein for Bovine Bile acid receptor
Protein for Bovine Bile acid receptor
Protein for Bovine Bile acid receptor
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Crossbred X Angus .
tissue :
Ileum .